Statistics Summary Report for ISPC Center

Last updated: Mar 11 2010

Target Status Statistics
- Table 1: Status Statistics for ISPC
- Table 2: Status Statistics for ISPC by Organisms
Deposited Structure Statistics
- Table 3: PDB Status Statistics for Structures from ISPC
- Table 4: List of Structures Deposited by ISPC in the PDB
Sequence Redundancy Statistics
- Table 5: Sequence Redundancy Statistics for ISPC by Experimental Status
- Table 6: Sequence Redundancy Statistics for Structures Released by ISPC in the PDB by Year

Target Status Statistics

Total number of targets deposited by ISPC to TargetDB: 136

View ISPC Target List

Table 1: Status Statistics for ISPC

Status	Total Number of Targets	(%) Relative to "Cloned" Targets	(%) Relative to "Expressed" Targets	(%) Relative to "Purified" Targets	(%) Relative to "Crystallized" Targets
Cloned	132	100.0	-	-	-
Expressed	107	81.1	100.0	-	-
Soluble	89	67.4	83.2	-	-
Purified	82	62.1	76.6	100.0	-
Crystallized	46	34.8	43.0	56.1	100.0
Diffraction-quality Crystals	34	25.8	31.8	41.5	73.9
Diffraction	0	0.0	0.0	0.0	0.0
NMR Assigned	0	0.0	0.0	0.0	-
HSQC	0	0.0	0.0	0.0	-
Crystal Structure	26	19.7	24.3	31.7	56.5
NMR Structure	0	0.0	0.0	0.0	-
In PDB1	14	10.6	13.1	17.1	30
Work Stopped	16	-	-	-	-
Test Target	0	-	-	-	-
Other	0	-	-	-	-

Last updated: Mar 11 2010

Table 2: Status Statistics for ISPC by Organism

These statistics are derived from mapping of target sequences to GenBank using >=98% sequence identity cut off

Organism	Total Number1	Work Stopped	Cloned	Expressed	Purified	Crystallized	Crystal Structure	NMR Structure	In PDB2
Viruses	6	0	5	3	1	0	0	0	0
Bacteria	70	10	70	54	39	25	12	0	5
Prokaryota	70	10	70	54	39	25	12	0	5
Arabidopsis	1	0	1	1	1	0	0	0	0
Drosophila	4	0	3	3	1	1	0	0	0
Mouse	15	2	15	12	10	2	1	0	1
Human	31	5	30	23	19	6	5	0	3
Eukaryota	60	5	57	49	42	20	14	0	9

Last updated: Mar 11 2010

Note 1: Total counts in this table may differ from total number of targets and structures. A target is counted in different organism specifications if:
- a target is mapped to different organisms
- a targtet is a hybrid complex (for example:a complex of human and mouse polypeptides)

Deposited Structure Statistics for ISPC Center

Number of Released X-Ray Structures: 13

Number of Released NMR Structures: 0

Total number of released structures from ISPC center in the PDB: 13

Table 3: PDB Status Statistics for Structures from ISPC

PDB Status	Number of Structures
Total Deposited	13
Released	13
Release on Publication	0
Release on Certain Date	0
In Process	0

Last updated: Mar 11 2010

Note 1: "Total Deposited" are all structures in the PDB including structures released to the public and structures that are in the process to be released("Released on Publication" , "Released on Certain Date", etc.).

Table 4: List of Structures Deposited in the PDB by ISPC

Total number of structures: 14

Structures of distinct targets: 141

1 A target may reference several PDB IDs (example: structure of the same polypeptides with different ligands).
In this case only one structure is counted to compute number of structures of distinct targets

Related PDB_ID(s): PDB_ID(s) associated with the same target in targetDB

PDB_ID	Title	Target_id	Deposition Date	Released Date	PDB Status	Related PDB_ID in TargetDB
2NVB	contribution of pro275 to the thermostability of the alcohol dehydrogenases (adhs)	W00208	2006-11-12	2007-11-13	REL	none
1ZGB	crystal structure of torpedo californica acetylcholinesterase in complex with an (r)-tacrine(10)-hupyridone inhibitor.	W00568	2005-04-21	2005-08-16	REL	none
1ZGC	crystal structure of torpedo californica acetylcholinesterase in complex with an (rs)-tacrine(10)-hupyridone inhibitor.	W00567	2005-04-21	2005-08-16	REL	none
1V04	serum paraoxonase by directed evolution	W00066	2004-03-22	2004-04-23	REL	none
2F1O	crystal structure of nqo1 with dicoumarol	W00027	2005-11-15	2006-05-16	REL	none
1OGS	human acid-beta-glucosidase	W00186	2003-05-13	2003-07-03	REL	none
1Y7V	x-ray structure of human acid-beta-glucosidase covalently bound to conduritol b epoxide	W00572	2004-12-10	2005-04-12	REL	none
2B5R	1b lactamase / b lactamase inhibitor	W00364	2005-09-29	2006-04-11	REL	none
1S0W	1b lactamse/ b lactamase inhibitor	W00187	2004-01-05	2004-02-10	REL	none
2B83	a single amino acid substitution in the clostridium beijerinckii alcohol dehydrogenase is critical for thermostabilization	W00283	2005-10-06	2006-09-19	REL	none
1Y7W	crystal structure of a halotolerant carbonic anhydrase from dunaliella salina	W00565	2004-12-10	2005-05-03	REL	none
1U65	ache w. cpt-11	W00566	2004-07-29	2005-07-19	REL	none
1XXM	the modular architecture of protein-protein binding site	W00178	2004-11-07	2005-01-18	REL	none
2OET	crystal structure of antizyme inhibitor	W00007	2007-01-01	0000-00-00	WDRN	none

Note 1: Last updated: Mar 11 2010

Sequence Redundancy Statistics

Table 5: Sequence Redundancy Statistics for ISPC by Experimental Status

Sequence Identity(%)	Novel Targets Status: Selected	Novel Targets Status: Cloned	Novel Targets Status: Expressed	Novel Targets Status: Purified	Novel Targets Status: Crystallized	Novel Targets Status: Crystal Structure	Novel Targets Status: in PDB
<100	110	106	84	59	31	17	10
<90	104	100	78	55	28	16	9
<70	97	93	72	50	23	11	8
<50	93	90	69	47	22	11	8
<30	77	77	67	47	22	11	8

Last updated: 10-03-08

Sequence redundancy is calculated by clustering analysis using BLASTClust program with similarity threshold set to percent of sequence identity. Please view detailed explanation of sequence redundancy calculations and BLASTClust threshold settings. Sequence redundancy calculations are based on comparison to all protein sequences in TargetDB which are in the same experimental status category and at least 20 amino acids long

Table 6:Sequence Redundancy Statistics for Structures Released by ISPC by Year

Year	Released Structures	Number of Released Structures <30% Identity at Time of Release	Percent(%) of Released Structures <30% Identity(%) at Time of Release
2003	1	1	100
2004	2	1	50
2005	6	0	0
2006	3	0	0
2007	1	0	0
Total	13	2	15

Last updated:10-03-11

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