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Statistics Summary Report for TB Center

                         Last updated: Jul 2 2008



Target Status Statistics

Total number of targets deposited by TB to TargetDB: 1603      View TB Target List

Table 1: Status Statistics for TB

Status Total Number of Targets(%) Relative to "Cloned" Targets(%) Relative to "Expressed" Targets(%) Relative to "Purified" Targets(%) Relative to "Crystallized" Targets
Cloned1113100.0---
Expressed84475.8100.0--
Soluble40035.947.4--
Purified32629.338.6100.0-
Crystallized19317.322.959.2100.0
Diffraction-quality Crystals1079.612.732.855.4
Diffraction1009.011.830.751.8
NMR Assigned10.10.10.3-
HSQC10.10.10.3-
Crystal Structure938.411.028.548.2
NMR Structure00.00.00.0-
In PDB1645.87.619.633
Work Stopped150----
Test Target0----
Other0----

Last updated: Jul 2 2008

Table 2: Status Statistics for TB by Organism

Organism Total Number1 Work Stopped Cloned Expressed Purified Crystallized Crystal Structure NMR Structure In PDB2
Bacteria1603150111384432619393064
Total Prokaryotes1603150111384432619393064
Total1603150111384432619393064

Last updated: Jul 2 2008

Note 1:   Total counts in this table may differ from total number of targets. If targtet is a hybrid complex
(for example:a complex of human and mouse polypeptides) it is counted in different organism classifications.

Note 2:   Number of targets with status "in PDB". A target may reference several PDB IDs (example: structure of the same polypeptides with different ligands).
Multiple targets in TargetDB may identify the same PDB structure when a stucture is a result of collaboration between different centers and each center includes
the target on its target list.
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Deposited Structure Statistics for TB Center

Number of Released X-Ray Structures: 115

Number of Released NMR Structures: 2

Total number of released structures from TB center in the PDB: 117

Table 3: PDB Status Statistics for Structures from TB

PDB StatusNumber of Structures
Total Deposited117
Released117
In Process0
Last updated: Jul 2 2008
Note 1:   "Total Deposited" are all structures in the PDB including structures released to the public and structures that are in the process to be released("Released on Publication" , "Released on Certain Date", etc.).

Table 4: List of Structures Deposited in the PDB by TB

Total number of structures: 117

Structures of distinct targets: 621

1   A target may reference several PDB IDs (example: structure of the same polypeptides with different ligands).
In this case only one structure is counted to compute number of structures of distinct targets

Related PDB_ID(s): PDB_ID(s) associated with the same target in targetDB

PDB_ID TitleTarget_id Deposition DateReleased Date PDB StatusRelated PDB_ID in TargetDB
2I6U crystal structure of ornithine carbamoyltransferase complexed with carbamoyl phosphate and l-norvaline from mycobacterium tuberculosis (rv1656) at 2.2 aRv16562006-08-292007-06-26REL2P2G
1YL5 crystal structure of mycobacterium tuberculosis dihydrodipicolinate reductase (rv2773c) (crystal form a)Rv2773c NON-XMTB:rv2773c2005-01-192006-01-17REL1YL6 1YL7
2C2Y three dimensional structure of bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase from mycobacterium tuberculosisRv3356c2005-09-302005-10-13RELnone
2Z76 x-ray crystal structure of rv0760c from mycobacterium tuberculosis at 1.82 angstrom resolutionRv0760c2007-08-162007-09-18RELnone
2FVH crystal structure of rv1848, a urease gamma subunit urea (urea amidohydrolase), from mycobacterium tuberculosisRv18482006-01-302006-02-07RELnone
2A7X crystal structure of a pantothenate synthetase complexed with ampRv3602c2005-07-062006-02-21RELnone
1N2H crystal structure of a pantothenate synthetase from m. tuberculosis in complex with a reaction intermediate, pantoyl adenylateRv3602c2002-10-222003-04-22RELnone
1XXX crystal structure of dihydrodipicolinate synthase (dapa, rv2753c) from mycobacterium tuberculosisRv2753c NON-XMTB:rv2753c2004-11-092006-02-14RELnone
1UE5 crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosisRv00542003-05-092004-02-10RELnone
1RFE crystal structure of conserved hypothetical protein rv2991 from mycobacterium tuberculosisRv29912003-11-082004-12-28RELnone
1YK3 crystal structure of rv1347c from mycobacterium tuberculosisRv1347c2005-01-162005-02-01RELnone
1U5V structure of cite complexed with triphosphate group of atp form mycobacterium tuberculosisRv2498c2004-07-282004-10-12RELnone
1QPN quinolinate phosphoribosyl transferase from mycobacterium tuberculosis in complex with ncnnRv15961998-11-201998-11-25REL1QPO 1QPQ 1QPR
1N2G crystal structure of a pantothenate synthetase from m. tuberculosis in complex with ampcppRv3602c2002-10-222003-04-22RELnone
2NQT crystal structure of n-acetyl-gamma-glutamyl-phosphate reductase (rv1652) from mycobacterium tuberculosis at 1.58 a resolutionRv16522006-10-312006-11-28RELnone
1MO4 reca-atp-gamma-s complexRv2737c2002-09-072003-02-18RELnone
1YL7 the crystal structure of mycobacterium tuberculosis dihydrodipicolinate reductase (rv2773c) in complex with nadh (crystal form c)Rv2773c NON-XMTB:rv2773c2005-01-192006-01-17RELnone
1KPG crystal structure of mycolic acid cyclopropane synthase cmaa1 complexed with sah and ctabRv3392c2001-12-302002-01-11RELnone
2A2J crystal structure of a putative pyridoxine 5'-phosphate oxidase (rv2607) from mycobacterium tuberculosisRv26072005-06-222005-08-23RELnone
1S8N crystal structure of rv1626 from mycobacterium tuberculosisRv1626 NON-XMTB:rv16262004-02-032004-09-21REL1SD5
1KPI crystal structure of mycolic acid cyclopropane synthase cmaa2 complexed with sah and dddmabRv0503c2001-12-302002-01-11RELnone
1ZEL crystal structure of rv2827c protein from mycobacterium tuberculosisRv2827c NON-XMTB:rv2827c2005-04-192006-05-02RELnone
2G5F the structure of mbti from mycobacterium tuberculosis, the first enzyme in the synthesis of mycobactin, reveals it to be a salicylate synthaseRv2386c2006-02-222006-09-05RELnone
1BVR m.tb. enoyl-acp reductase (inha) in complex with nad+ and c16-fatty-acyl-substrateRv14841998-09-171999-09-17REL1ENY 1ENZ 1P44 1P45 1ZID
1YWF crystal structure of mycobacterium tuberculosis protein tyrosine phosphatase ptpbRv0153c2005-02-172005-11-22RELnone
1SJP mycobacterium tuberculosis chaperonin60.2Rv04402004-03-042004-12-07REL2AO2
2P2G crystal structure of ornithine carbamoyltransferase from mycobacterium tuberculosis (rv1656): orthorhombic formRv16562007-03-072007-07-03RELnone
1QPQ structure of quinolinic acid phosphoribosyltransferase from mycobacterium tuberculosis: a potential tb drug targetRv15961998-11-201998-11-25RELnone
1MOP crystal structure of a pantothenate synthetase from m. tuberculosisRv3602c2002-09-092003-03-11REL1N2B 1N2E 1N2G 1N2H 1N2I 1N2J 1N2O 2A7X 2A84 2A86 2A88
1TXO crystal structure of the mycobacterium tuberculosis serine/threonine phosphatase pstp/ppp at 1.95 a.Rv0018c2004-07-052004-11-23RELnone
2C2X three dimensional structure of bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolas from mycobacterium tuberculosisRv3356c2005-09-302005-10-13REL2C2Y
1P44 targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural dataRv14842003-04-212003-09-16RELnone
1XVQ crystal structure of thiol peroxidase from mycobacterium tuberculosisRv19322004-10-282004-12-07RELnone
2A7Y solution structure of the conserved hypothetical protein rv2302 from the bacterium mycobacterium tuberculosisRv23022005-07-062005-08-23RELnone
1VS0 crystal structure of the ligase domain from m. tuberculosis ligd at 2.4aRv09382006-01-272006-02-28RELnone
1G18 reca-adp-alf4 complexRv2737c2000-10-112000-12-11REL1G19 1MO3 1MO4 1MO5 1MO6
2G38 a pe/ppe protein complex from mycobacterium tuberculosisRv2430c TB:Rv2431c ISFI:ISFI141 ISFI:ISFI1422006-02-172006-03-14RELnone
1N2E crystal structure of a pantothenate synthetase from m. tuberculosis in complex with ampcpp and pantoateRv3602c2002-10-222003-04-22RELnone
2A15 x-ray crystal structure of rv0760 from mycobacterium tuberculosis at 1.68 angstrom resolutionRv0760c2005-06-172005-10-11REL2Z76 2Z77 2Z7A
1N2O crystal structure of pantothenate synthetase from m. tuberculosis, low occupancy of beta-alanine at the pantoate binding sitesRv3602c2002-10-232003-04-23RELnone
2GP6 x-ray crystal structure of mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase ii (mtkasb)Rv22462006-04-172006-07-18RELnone
2FGG crystal structure of rv2632cRv2632c2005-12-212006-02-14RELnone
1DQZ crystal structure of antigen 85c from mycobacterium tuberculosisRv0129c2000-01-052000-07-12RELnone
1HTO crystallographic structure of a relaxed glutamine synthetase from mycobacterium tuberculosisRv22202001-01-012002-07-24REL1HTQ
1NYO solution structure of the antigenic tb protein mpt70/mpb70Rv28752003-02-132003-08-19RELnone
1Z6K citrate lyase beta subunit complexed with oxaloacetate and magnesium from m. tuberculosisRv2498c2005-03-222005-05-03RELnone
1KP9 crystal structure of mycolic acid cyclopropane synthase cmaa1, apo-formRv3392c2001-12-302002-01-11REL1KPG 1KPH
2A88 crystal structure of a pantothenate synthetase, apo enzyme in c2 space groupRv3602c2005-07-072006-02-21RELnone
2G2D crystal structure of a putative pduo-type atp:cobalamin adenosyltransferase from mycobacterium tuberculosisRv1314c ISFI:ISFI152006-02-152006-03-28RELnone
2AQ6 x-ray crystal structure of mycobacterium tuberculosis pyridoxine 5'-phosphate oxidase complexed with pyridoxal 5'-phosphate at 1.7 a resolutionRv11552005-08-172005-08-30RELnone
1M1M x-ray crystal structure of mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase iii (mtfabh)Rv0533c2002-06-192002-07-17RELnone
1Q7T rv1170 (mshb) from mycobacterium tuberculosisRv11702003-08-202004-01-13RELnone
1Z9W tetrameric structure of apo-7,8-dihydroneopterin aldolase from mycobacterium tuberculosisRv3607c2003-10-212004-11-02RELnone
2I3G crystal structure of n-acetyl-gamma-glutamyl-phosphate reductase (rv1652) from mycobacterium tuberculosis in complex with nadp+.Rv16522006-08-182006-09-05RELnone
1N2B crystal structure of a pantothenate synthetase from m. tuberculosis in complex with ampcpp and pantoate, higher occupancy of pantoate and lower occupancy of ampcpp in subunit aRv3602c2002-10-222003-04-22RELnone
2I3A crystal structure of n-acetyl-gamma-glutamyl-phosphate reductase (rv1652) from mycobacterium tuberculosisRv16522006-08-172006-08-29REL2I3G 2NQT
1Q74 the crystal structure of 1d-myo-inosityl 2-acetamido-2-deoxy-alpha-d-glucopyranoside deacetylase (mshb)Rv11702003-08-152003-12-02REL1Q7T
2FSX crystal structure of rv0390 from m. tuberculosisRv03902006-01-232006-02-07RELnone
1ZZO structure of mtb dsbf in its oxidized form.Rv16772005-06-142005-07-26RELnone
1U0R crystal structure of mycobacterium tuberculosis nad kinaseRv16952004-07-142004-08-31REL1U0T
1DQY crystal structure of antigen 85c from mycobacterium tuberculosis with diethyl phosphate inhibitorRv0129c2000-01-052000-07-12REL1DQZ 1VA5
2A86 crystal structure of a pantothenate synthetase complexed with amp and beta-alanineRv3602c2005-07-072006-02-21RELnone
1NBU 7,8-dihydroneopterin aldolase complexed with product from mycobacterium tuberculosisRv3607c2002-12-032004-01-13REL1Z9W
2A6P structure solution to 2.2 angstrom and functional characterisation of the open reading frame rv3214 from mycobacterium tuberculosisRv32142005-07-032006-05-16RELnone
2A87 crystal structure of m. tuberculosis thioredoxin reductaseRv39132005-07-072005-11-29RELnone
2AO2 the 2.07 angstrom crystal structure of mycobacterium tuberculosis chorismate mutase reveals unexpected gene duplication and suggests a role in host-pathogen interactionsRv0440 TB:Rv1885c2005-08-122006-06-13RELnone
1MO5 reca-atp-gamma-s-mg complexRv2737c2002-09-072003-02-18RELnone
1F0N mycobacterium tuberculosis antigen 85bRv1886c2000-05-162001-01-24REL1F0P
1HTQ multicopy crystallographic structure of a relaxed glutamine synthetase from mycobacterium tuberculosisRv22202001-01-012002-07-24RELnone
2Z77 x-ray crystal structure of rv0760c from mycobacterium tuberculosis in complex with estradiol-17beta-hemisuccinateRv0760c2007-08-162007-09-18RELnone
1ENY crystal structure and function of the isoniazid target of mycobacterium tuberculosisRv14841995-01-271996-01-29RELnone
1XVW crystal structure of ahpe from mycobacterium tuberculosis, a 1-cys peroxiredoxinRv2238c2004-10-282005-02-22REL1XXU
1N2I crystal structure of pantothenate synthetase from m. tuberculosis in complex with a reaction intermediate, pantoyl adenylate, different occupancies of pantoyl adenylateRv3602c2002-10-222003-04-22RELnone
1EYV the crystal structure of nusb from mycobacterium tuberculosisRv2533c2000-05-092000-05-18RELnone
1SFR crystal structure of the mycobacterium tuberculosis antigen 85a proteinRv3804c2004-02-202004-07-06RELnone
1Y8T crystal structure of rv0983 from mycobacterium tuberculosis- proteolytically active formRv09832004-12-132005-01-18RELnone
1L1E crystal structure of mycolic acid cyclopropane synthase pcaa complexed with s-adenosyl-l-homocysteineRv0470c2002-02-152002-03-06RELnone
2ASF crystal structure of the conserved hypothetical protein rv2074 from mycobacterium tuberculosis 1.6 aRv20742005-08-232005-10-11RELnone
1ENZ crystal structure and function of the isoniazid target of mycobacterium tuberculosisRv14841995-01-271996-01-29RELnone
1XXO x-ray crystal structure of mycobacterium tuberculosis pyridoxine 5'-phosphate oxidase at 1.8 a resolutionRv11552004-11-072004-11-16REL1Y30 2AQ6
1P45 targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural dataRv14842003-04-212003-09-16RELnone
1N2J crystal structure of a pantothenate synthetase from m. tuberculosis in complex with pantoateRv3602c2002-10-222003-04-22RELnone
2A84 crystal structure of a pantothenate synthetase complexed with atpRv3602c2005-07-072006-02-21RELnone
1Y0H structure of rv0793 from mycobacterium tuberculosisRv07932004-11-152004-12-28RELnone
1ZVW the crystal structure of trpd (rv2192c) from mycobacterium tuberculosis in complex with prpp and magnesiumRv2192c2005-06-022006-01-17REL2BPQ
2FR2 crystal structure of rv2717c from m. tuberculosisRv2717c2006-01-182006-01-31RELnone
1Y30 x-ray crystal structure of mycobacterium tuberculosis pyridoxine 5'-phosphate oxidase complexed with flavin mononucleotide at 2.2 a resolutionRv11552004-11-232005-08-30RELnone
1QPR quinolinate phosphoribosyltransferase (qaprtase) from mycobacterium tuberculosis in complex with phthalate and prpcpRv15961998-10-171998-10-21RELnone
1MRU intracellular ser/thr protein kinase domain of mycobacterium tuberculosis pknb.Rv0014c2002-09-182003-02-11REL1O6Y
1ZID long fatty acid chain enoyl-acp reductase (inha) in complex with an isonicotinic-acyl-nadh inhibitorRv14841997-03-251998-03-25RELnone
1YL6 crystal structure of mycobacterium tuberculosis dihydrodipicolinate reductase (rv2773c) (crystal form b)Rv2773c NON-XMTB:rv2773c2005-01-192006-01-17RELnone
1F0P mycobacterium tuberculosis antigen 85b with trehaloseRv1886c2000-05-162001-01-24RELnone
1U0T crystal structure of mycobacterium tuberculosis nad kinaseRv16952004-07-142004-08-31RELnone
2GDN crystal structure of the mycobacterium tuberculosis beta-lactamaseRv2068c2006-03-162006-04-18RELnone
1KPH crystal structure of mycolic acid cyclopropane synthase cmaa1 complexed with sah and dddmabRv3392c2001-12-302002-01-11RELnone
1MO3 reca-adp complexRv2737c2002-09-072003-02-18RELnone
1XXU crystal structure of ahpe from mycrobacterium tuberculosis, a 1-cys peroxiredoxinRv2238c2004-11-082005-02-22RELnone
1UE7 crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosisRv00542003-05-092004-02-10RELnone
1K0R crystal structure of mycobacterium tuberculosis nusaRv2841c2001-09-202001-12-21RELnone
1LU4 1.1 angstrom resolution crystal structure of a secreted mycobacterium tuberculosis disulfide oxidoreductase homologous to e. coli dsbe: implications for functionsRv2878c2002-05-212003-10-14RELnone
1UE6 crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosisRv00542003-05-092004-02-10RELnone
1VA5 antigen 85c with octylthioglucoside in active siteRv0129c2004-02-112004-07-06RELnone
1NWA structure of mycobacterium tuberculosis methionine sulfoxide reductase a in complex with protein-bound methionineRv0137c2003-02-052003-07-08RELnone
1SD5 crystal structure of rv1626Rv1626 NON-XMTB:rv16262004-02-132004-09-21RELnone
1RWI extracellular domain of mycobacterium tuberculosis pkndRv0931c2003-12-162004-04-27REL1RWL
1RWL extracellular domain of mycobacterium tuberculosis pkndRv0931c2003-12-162004-04-27RELnone
1MO6 reca-datp-mg complexRv2737c2002-09-072003-02-18RELnone
1G19 structure of reca proteinRv2737c2000-10-112000-12-11RELnone
1UE1 crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosisRv00542003-05-082004-02-10REL1UE5 1UE6 1UE7
1QPO quinolinate phosphoribosyl transferase (qaprtase) apo-enzyme from mycobacterium tuberculosisRv15961998-11-211998-11-24RELnone
1U5H structure of citrate lyase beta subunit from mycobacterium tuberculosisRv2498c2004-07-272004-10-12REL1U5V 1Z6K
1O6Y catalytic domain of pknb kinase from mycobacterium tuberculosisRv0014c NON-SPINE:IPRv0014cPALZ2002-10-212003-01-30RELnone
1LMI 1.5 angstrom resolution crystal structure of a secreted protein from mycobacterium tuberculosis-mpt63Rv1926c2002-05-012002-12-04RELnone
2BPQ anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (apo structure)Rv2192c2005-04-212006-01-04RELnone
2B70 t4 lysozyme mutant l99a at ambient pressureRv2178c2005-10-032005-11-08RELnone
2Z7A x-ray crystal structure of rv0760c from mycobacterium tuberculosis at 2.10 angstrom resolutionRv0760c2007-08-172007-09-11RELnone
2D2Y crystal structure of the conserved hypothetical protein rv1873 from mycobacterium tuberculosis at 1.58 aRv18732005-09-212005-10-11Replaced by:2JEKnone

Note 1:  Last updated: Jul 2 2008

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Sequence Redundancy Statistics

Table 5: Sequence Redundancy Statistics for TB by Experimental Status

Sequence Identity(%)Novel Targets
Status:
Selected
Novel Targets
Status:
Cloned
Novel Targets
Status:
Expressed
Novel Targets
Status:
Purified
Novel Targets
Status:
Crystallized
Novel Targets
Status:
Crystal Structure
Novel Targets
Status:
in PDB
<100160211128443261939364
<90159611088423261939364
<70158110988383231909162
<50150110468123141858960
<3011368897243071808860
Last updated: 08-04-08
Sequence redundancy is calculated by clustering analysis using BLASTClust program with similarity threshold set to percent of sequence identity.   Please view detailed explanation of sequence redundancy calculations and BLASTClust threshold settings.  Sequence redundancy calculations are based on comparison to all protein sequences in TargetDB which are in the same experimental status category and at least 20 amino acids long

Table 6:Sequence Redundancy Statistics for Structures Released by TB by Year

Year Released Structures Number of Released Structures <30% Identity at Time of Release Percent(%) of Released Structures <30% Identity(%) at Time of Release
<= 200013215
2001300
20029111
200320420
200423626
200518739
200626519
2007500
Total1172521
Last updated:08-07-02
Sequence redundancy is calculated by clustering analysis using BLASTClust program with similarity threshold set to percent of sequence identity.   Please view detailed explanation of sequence redundancy calculations and BLASTClust threshold settings.  Sequence redundancy calculations are based on comparison to all protein sequences in the PDB which are at least 20 amino acids long
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